Which major river runs through Alaska?

The Yukon River is the major river that runs through Alaska, making it the correct choice. This river is one of the longest in North America, with a length of approximately 1,980 miles. It originates in the Canadian Yukon Territory, flows through Alaska, and eventually empties into the Bering Sea. The Yukon River has significant historical and cultural importance, particularly for the Native Alaskan communities and during the Klondike Gold Rush, which led to a rapid influx of people to the region in the late 19th century.

The other rivers mentioned, such as the Columbia, Missouri, and Mississippi, are not located in Alaska. The Columbia River primarily flows through the states of Washington and Oregon, while the Missouri and Mississippi rivers are predominantly found in the central United States. Hence, the Yukon stands out as the major river associated with Alaska.