What wildlife refuge is the largest of its kind in the U.S. and located in Alaska?

The Arctic National Wildlife Refuge holds the distinction of being the largest wildlife refuge in the United States, covering over 19 million acres. It is located in northeastern Alaska and is renowned for its diverse ecosystems, providing habitat for a variety of species, including polar bears, caribou, and migratory birds. The refuge's vast landscapes range from coastal plains to rugged mountains, making it a crucial area for conservation and wildlife protection.

In contrast, the other options listed are all significant national parks but do not specialize in being wildlife refuges nor do they cover as expansive an area as the Arctic National Wildlife Refuge. Each of those parks has its unique features and ecological importance, but none matches the size and the specific designation of a wildlife refuge as effectively as the Arctic National Wildlife Refuge does.